OleaPharma : Clôture définitive de nos activités

Qualitative and quantitative composition
Fipronil 50 mg . Butylhydroxyanisole ( E320 ) 0.10 mg . Butylated hydroxytoluene ( E321 ) 0.05 mg . Ethanol 0.05 ml . Excipient 1 pipette 0.5 ml .
pharmaceutical form
Spot-on solution .
target species
Cats.
Indications for use, specifying the target species
Conditions sensitive to fipronil parasites.
In cats :
- Preventive and curative treatment of flea infestations (Ctenocephalides felis ) and ticks ( Rhipicephalus spp spp Dermacentor and Ixodes spp. . . .)
- Elimination of biting lice ( Felicola subrostratus ) .

The duration of protection against new infestations is 4 weeks for fleas and 2 weeks for ticks.

The drug may be part of a treatment program Allergy Dermatitis Flea ( FAD).
Cons -indications
In the absence of available data , do not treat kittens under 8 weeks of age or weighing less than 1 kg .
Do not use on sick ( systemic diseases, fever ... ) or convalescent .
Do not use in rabbits because of the sometimes lethal side effects may occur .
Special precautions for the person administering the veterinary medicinal product to animals
This product may cause irritation to mucous membranes and eyes. So avoid contact with the mouth and eyes.
Animals or users with a known hypersensitivity to insecticides or alcohol should avoid contact with the drug. Avoid contact of the contents with your fingers. If this occurs , wash hands with soap and water .
In case of accidental exposure with eyes, rinse with clean water carefully . Wash hands after use.
Do not handle animals treated and not allow children to play with treated animals until the application site is dry . It is therefore recommended that animals are not treated during the day but in the early evening , and that recently treated animals are not allowed to sleep with owners, especially children. Do not smoke, drink or eat during application.

Special warnings for each target species
Avoid contact with the eyes of the animal.
Special precautions for use in animals
It is important to make sure to apply the dose to an area where the animal can not lick it off and to ensure that animals do not lick them .
Data evaluating the effect of a bath or shampoo on the effectiveness of the product in cats are not available . However, on the basis of available information in dogs shampooed from 2 days after application of the product, it is not recommended to bathe the animals in the two days following the application.

Attached ticks may occasionally be observed. For this reason, the transmission of infectious diseases can not be completely excluded if conditions are unfavorable.
Fleas from pets often infest their basket , their sleeping area and regular resting areas such as carpets and sofas . In case of massive and early treatment infestation , these areas should be treated with a suitable insecticide and vacuumed regularly .
Special precautions for the person administering the medicinal product to animals
This product may cause irritation to mucous membranes and eyes. So avoid contact with the mouth and eyes.
Animals or users with a known hypersensitivity to insecticides or alcohol should avoid contact with the drug.
Avoid contact of the contents with your fingers. If this occurs , wash hands with soap and water .
In case of accidental eye exposure , flush with clean water carefully .
Wash hands after use.
Do not handle animals treated and not allow children to play with treated animals until the application site is dry . It is therefore recommended that animals are not treated during the day but in the early evening , and that recently treated animals are not allowed to sleep with owners, especially children.
Do not smoke, drink or eat during application.
Adverse reactions (frequency and seriousness)
If licking , a brief period of hypersalivation due to the nature of the carrier can be observed .
Among the extremely rare suspected side effects , transient skin reactions at the application ( scaling, local alopecia , pruritus, erythema ) and general pruritus or alopecia site have been reported. Exceptionally, hypersalivation , reversible neurological signs ( hyperaesthesia , depression, nervous signs ) or vomiting have been observed after use.
Do not overdose .
Use during pregnancy, lactation or lay and
Specialty may be used during pregnancy and lactation.
Drug interactions and other forms of interaction
Unknown .
dosage
0.5 ml of solution per animal under the skin .
In the absence of safety data , the minimum treatment interval is 4 weeks .
Method of administration
Completely empty the pipette directly on the skin , holding the hair of the animal, preferably at two points at the base of the neck and between the shoulders to prevent licking.
Overdose (symptoms, emergency procedures, antidotes), if necessary
No adverse effects have been demonstrated in studies of tolerance in cats and kittens 8 weeks or more and having a weight of about 1 kg treated every month for 6 months to 5 times the recommended dose. The risk of experiencing adverse effects may however increase in cases of overdose ( see section "Undesirable effects" ) .
Some itching may occur after treatment.
An overdose of this product may cause a sticky appearance of hairs at the site of application. However , in this case , these signs disappear within 24 hours after application .
Waiting time
Not applicable.
pharmacological properties

Pharmacotherapeutic group : Pest control for external use.
ATC vet code : QP53AX15 .
Pharmacodynamic properties
Fipronil is an insecticide acaricide belonging to the family of phenylpyrazoles . It works by inhibiting the GABA complex , thereby blocking the transfer of chloride ions across the membrane at the pre- and postsynaptic by binding in the chlorine channel . It thus causing uncontrolled activity of the central nervous system and death of insects and mites.
pharmacokinetic characteristics
After application, it establishes on the animal's coat a concentration gradient of fipronil ( translocation ) from the point of application to outlying areas ( lumbar region , flanks, ... ) . Over time , the concentration of fipronil in the bristles are descending to an average concentration of about 3-4 g / g of hair , 56 days after treatment. This extended fipronil on the hair persistence is explained by the accumulation of fipronil in the sebaceous glands and progressive release together with the sebum.
In dogs, the transcutaneous passage of fipronil is low.
Fipronil is metabolized to its sulfone derivative.
List of excipients

Ethanol
polysorbate 80
povidone
Buthylhydroxyanisole ( E320 )
Buthylhydroxytoluène ( E321 )
Diethylene glycol monoethyl ether
incompatibilities
Unknown .
Shelf Life
3 years .
Special precautions for storage
Do not store above 30 ° C.
Keep away from moisture.
Nature and composition of immediate packaging
Barex 210- polypropylene pipette .
Special precautions for disposal of unused medicinal products or waste materials derived from the use of these drugs precautions
Empty packaging and any remaining product should be disposed of following the practices governed by regulations on waste.
Fipronil may adversely affect aquatic organisms. Do not dispose of the product or empty containers in ponds , rivers or streams.